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Program Head: Professor Glenn Marshall (biography)
RESEARCH AREAS
Neuroblastoma tumour formation
Retinoid therapy for neuroblastoma
Initiation of childhood leukaemia
Brain cancer
Experimental Therapeutics
The Molecular Carcinogenesis Program focuses on two themes: (i) the molecules and processes that initiate childhood cancer and (ii) defining therapies for childhood cancer which have a low side-effect profile combined with a high level of effectiveness. At present, very little is known of the factors that initiate cancer in children. An increased understanding of such factors is likely to be important in developing preventative strategies. A major problem with conventional anticancer chemotherapy in childhood cancer patients is the high level of side effects that occur. Developing therapies that destroy cancer cells and not normal cells will help overcome this problem.
STUDENT PROJECTS
- Role of Myc Box II domain of MycN in neuroblastoma tumour initiation
- Role of the tumour suppressor protein, p53 in the embryonal oncogenic process
- Role of N-myc target genes in neuroblastoma tumour initiation (NB)
- The role of histone deacetylase in Myc-induced tumourigenesis
- The role of histone methylation in neuroblastoma
- The role of Estrogen-responsive B Box Protein (EBBP) as a tumour suppressor in skin carcinogenesis
- The role of histone deacetylase in Myc-induced tumourigenesis
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